Host Defence Peptides
Posters and publications
HIGH RISK PATIENTS AND UNMET NEED – WHY AND WHAT WE AIM TO DO
In immunocompromized patients, Influenza is associated to a significantly higher number of radiographic abnormalities and severe complications, require more intensive care and mechanical ventilation.1
Prolonged influenza shedding is also observed in these patients which contributes to viral spread in the general population.
- The population with highest risk of mortality are haematopoietic stem cell transplant2 (HSCT) patients, but also other conditions such as:
– Hematologic malignancies and solid organ tumor patients
– Patients who receive other immunosuppressive therapies
- Furthermore, Influenza vaccines have highly variable efficacy that is hard to predict
- High Influenza viral load titers seem to correlate with worse outcome and increased risk of mortality3
- Current treatment options do not have a meaningful impact symptom duration4 in these patients. In addition, they are replication inhibitors as opposed to LTX-109s direct virucidal effect.
LTX-109, as a direct virucidal, will demonstrate reduction in hospitalisation, mortality and symptom duration in clinical trials in non-hospitalized early stage HSCT influenza patients as an add-on to standard of care.
- Influenza virus load in hospitalised patients, N Lee et al. Hong Kong Med J 2013 & The severity and risk factors for mortality in immunocompromised adult patients hospitalized with influenza-related pneumonia,Chen et al. 2021
- Respiratory virus infections in stem cell transplant patients: the European experience. Biol Blood Marrow Transplant. Ljungman P. Et al. 2001
- a) Viral Factors Associated With the High Mortality Related to Human Infections With Clade 2.1 Influenza A/H5N1 Virus in Indonesia Pavestri et al 2020 Clinical infectious disease b) Every 10-fold increase in viral load results in 26% more patient deaths: a correlation analysis, Jiang et al. Int J Clin Exp Med 2019. c) Influence of viral load in the outcome of hospitalized patients with influenza virus infection, Lalueza et al.
- 4 Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. T Jefferson et al. Cochrane Database of Systematic Reviews 2014