About us



Pharma Holdings AS

Pharma Holdings AS develops novel drugs for treatment of microbial infections (including multi-resistant microbes, and difficult-to-treat microbes). The Company was founded in 2017 as a spin-off of Lytix Biopharma, which was established in 2003 to commercialize world-class research in the field of lytic peptides. The technology was founded by scientists working at the University of Tromsø and University Hospital of Tromsø, Norway.

Strengths of Pharma Holdings position:

  • Large market, large unmet need, with increasing opportunities
  • World-class science
  • Diversity of indications
  • Potential for new opportunities beyond the initial indications (e.g. through reformulation and new administration routes)
  • Multi-level partnering opportunities

Lead compound

LTX-109 is our lead compound. It is an investigational antimicrobial drug with a novel membrane-lysing mechanism of action, based on the biological principle of innate immune effectors, lytic peptides. The drug has an unparalleled rapid bactericidal activity. Further, LTX-109 has been tested in in vitro and in vivo models and has undergone a comprehensive nonclinical safety and toxicology programs. It has been studied in man in a Phase I study, two phase I/IIa studies and one phase II PoC study. The drug is currently in development as a gel in treatment for skin conditions with a linked infectious component and for nasal decolonization of S. aureus pre-operatively.

The following clincial trials are completed:

Phase I in healthy volunteers; 37 patients (1%, 2% and 5% LTX-109 and vehicle/placebo)
Phase I/IIa pilot study in Gram+ skin infections; 24 patients (1%, 2% and 5% LTX-109 and vehicle/placebo)
Phase I/IIa pilot study nasal decolonisation completed; 24 patients (1%, 2% and 5% LTX-109 and vehicle/placebo)
Phase II PoC study impetigo;187 patients (1% and 2% LTX-109 and vehicle/placebo)