Science

Nature's own defence mechanism

Host Defence Peptides and Antimicrobial Peptides

Our drugs are based the principles of host defence peptides. The molecules are modifications of peptides found in the bovine Lactoferrin protein, abundant in cow-milk. Host defence peptides (HDPs) are an evolutionarily ancient component of the innate immune system of most multicellular organisms.(1)

Antimicrobial peptides of multicellular organisms

Mechanism of lysing action. Illustration by

Michael Zasloff, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6059, USA

NATURE |VOL 415 | 24 JANUARY 2002 |www.nature.com

Lactoferrin

The lactoferrin protein is found in milk and is known to have direct
anti-microbial activity and cancer immune modulatory effects.

Lactoferrin and Lactoferricin (blue)

Lactoferricin

Lactoferricin is an amphipathic, cationic peptide with anti-microbial and anti-cancer properties. It can be generated by the pepsin-mediated digestion of lactoferrin. Lactoferricin is the most studied AMP (Antimicrobial Peptide) derived from milk protein.

Structure-activity-relationship studies on Lactoferricin have resulted in the design of optimal molecules originating from the Company’s technology platform; the anti-infective drugs LTX-109 and LTX-105.

Derived from Lactoferricin; LTX-109

1. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature. 2002;415:389–95. [PubMed] []

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